异柠檬酸脱氢酶
苹果酸脱氢酶
硒
柠檬酸循环
琥珀酸脱氢酶
脱氢酶
致癌物
生物化学
酶
化学
生物
有机化学
作者
Chinnasamy Thirunavukkarasu,Jaswant Singh,K. Selvendiran,Dhanapal Sakthisekaran
摘要
Abstract The chemopreventive/chemotherapeutic effect of sodium selenite on tricarboxylic acid cycle key enzymes was investigated against hepatoma induced by environmental carcinogen N‐nitrosodiethylamine. Decreased activities of TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and α‐ketoglutarate dehydrogenase (α‐KGDH) in hepatoma and surrounding tissues of hepatoma‐bearing rats were observed. Upon selenium supplementation the above biochemical changes were reverted in a dose‐ and duration‐dependent manner. This study further confirms the chemopreventive/chemotherapeutic effect of sodium selenite which is found to be more effective in the initiation phase of carcinogenesis. Copyright © 2001 John Wiley & Sons, Ltd.
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