奶油
长时程增强
莫里斯水上航行任务
转基因小鼠
转基因
磷酸化
药理学
海马体
神经科学
生物
内分泌学
心理学
内科学
化学
细胞生物学
医学
生物化学
转录因子
受体
基因
作者
Ziping Wang,Xiaolong Li,Xiaotong Ren,Siqi Zhao,Wenwen Chen,Fan Cheng,Yangliu Xu,Xuejiao Pi,Yidan Zhang,Ting Wang,Shuang Rong
出处
期刊:Current Pharmaceutical Biotechnology
[Bentham Science]
日期:2023-10-01
卷期号:24 (12): 1560-1567
被引量:2
标识
DOI:10.2174/1389201024666230209142145
摘要
Alzheimer's disease (AD) is an age-related neurodegenerative disease and is featured by cognitive impairment. Procyanidins have been shown to have a potential protective effect against neurodegenerative diseases, but the underlying mechanism is not comprehensive enough.To further investigate the effects of procyanidins from lotus seedpod (LSPC) on cognition in AD.The APP/PS1 transgenic mice were administered with LSPC (100 mg/kg body weight) for five months. The Morris water maze test was used to assess learning and memory function, the long-term potentiation (LTP) was measured, and the expressions of Aβ, pCREB/CREB and BDNF were quantified by western blot.LSPC significantly ameliorated cognitive dysfunction, reduced Aβ deposition and reversed the remarkable reduction of the phosphorylation of CREB and the expression of BDNF, and then enhanced the effect of LTP in APP/PS1 mice.These results revealed that LSPC could ameliorate cognitive impairment through the CREB-BDNF pathway that mediates the enhancement of LTP in APP/PS1 transgenic mice.
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