纳米技术
再生(生物学)
摩擦电效应
再生医学
组织工程
生物医学工程
生物电子学
骨组织
材料科学
神经科学
生化工程
干细胞
工程类
生物
细胞生物学
复合材料
生物传感器
作者
Shichang Liu,Farid Manshaii,Jinmiao Chen,Xinfei Wang,Shaolei Wang,Junyi Yin,Ming Yang,Xuxu Chen,Xinhua Yin,Yunlei Zhou
标识
DOI:10.1007/s40820-024-01536-9
摘要
Abstract The incidence of large bone defects caused by traumatic injury is increasing worldwide, and the tissue regeneration process requires a long recovery time due to limited self-healing capability. Endogenous bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and regeneration. Inspired by bioelectricity, electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix, thereby accelerating bone regeneration. With ongoing advances in biomaterials and energy-harvesting techniques, electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone tissue. In this review, we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and tissue. Next, we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue engineering. Finally, we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.
科研通智能强力驱动
Strongly Powered by AbleSci AI