An integrated wearable differential microneedle array for continuous glucose monitoring in interstitial fluids

可穿戴计算机 生物医学工程 材料科学 计算机科学 持续监测 微流控 生物相容性 连续血糖监测 纳米技术 嵌入式系统 工程类 医学 内分泌学 运营管理 血糖性 胰岛素 冶金
作者
Yong Yang,Can Sheng,Fang Dong,Sheng Liu
出处
期刊:Biosensors and Bioelectronics [Elsevier]
卷期号:256: 116280-116280 被引量:5
标识
DOI:10.1016/j.bios.2024.116280
摘要

Monitoring biomarkers in human interstitial fluids (ISF) using microneedle sensors has been extensively studied. However, most of the previous studies were limited to simple in vitro demonstrations and lacked system integration and analytical performance. Here we report a miniaturized, high-precision, fully integrated wearable electrochemical microneedle sensing device that works with a customized smartphone application to wirelessly and in real-time monitor glucose in human ISF. A microneedle array fabrication method is proposed which enables multiple individually addressable, regionally separated sensing electrodes on a single microneedle system. As a demonstration, a glucose sensor and a differential sensor are integrated in a single sensing patch. The differential sensing electrodes can eliminate common-mode interference signals, thus significantly improving the detection accuracy. The basic mechanism of microneedle penetration into the skin was analyzed using the finite element method (FEM). By optimizing the structure of the microneedle, the puncture efficiency was improved while the puncture force was reduced. The electrochemical properties, biocompatibility, and system stability of the microneedle sensing device were characterized before human application. The test results were closely correlated with the gold standard (blood). The platform can be used not only for glucose detection, but also for various ISF biomarkers, and it expands the potential of microneedle technology in wearable sensing.
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