Electromicrofluidic Device for Interference-Free Rapid Antibiotic Susceptibility Testing of Escherichia coli from Real Samples

抗生素 抗生素耐药性 环丙沙星 阿莫西林 克拉维酸 抗菌剂 微生物学 生物
作者
Sonal Fande,Khairunnisa Amreen,D. Sriram,Valentin Mateev,Sanket Goel
出处
期刊:Sensors [MDPI AG]
卷期号:23 (23): 9314-9314 被引量:4
标识
DOI:10.3390/s23239314
摘要

Antimicrobial resistance (AMR) is a global health threat, progressively emerging as a significant public health issue. Therefore, an antibiotic susceptibility study is a powerful method for combating antimicrobial resistance. Antibiotic susceptibility study collectively helps in evaluating both genotypic and phenotypic resistance. However, current traditional antibiotic susceptibility study methods are time-consuming, laborious, and expensive. Hence, there is a pressing need to develop simple, rapid, miniature, and affordable devices to prevent antimicrobial resistance. Herein, a miniaturized, user-friendly device for the electrochemical antibiotic susceptibility study of Escherichia coli (E. coli) has been developed. In contrast to the traditional methods, the designed device has the rapid sensing ability to screen different antibiotics simultaneously, reducing the overall time of diagnosis. Screen-printed electrodes with integrated miniaturized reservoirs with a thermostat were developed. The designed device proffers simultaneous incubator-free culturing and detects antibiotic susceptibility within 6 h, seven times faster than the conventional method. Four antibiotics, namely amoxicillin–clavulanic acid, ciprofloxacin, ofloxacin, and cefpodoxime, were tested against E. coli. Tap water and synthetic urine samples were also tested for antibiotic susceptibility. The results show that the device could be used for antibiotic resistance susceptibility testing against E. coli with four antibiotics within six hours. The developed rapid, low-cost, user-friendly device will aid in antibiotic screening applications, enable the patient to receive the appropriate treatment, and help to lower the risk of anti-microbial resistance.
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