免疫系统
平衡
免疫学
生物
造血干细胞移植
人类白细胞抗原
CD8型
移植
T细胞
造血
干细胞
医学
细胞生物学
抗原
内科学
作者
Xiao‐Jun Huang,Huidong Guo,Liping Guo,Bixia Wang,Xinya Jiang,Zhigui Wu,Xiao‐Dong Mo,Yu‐Qian Sun,Yuanyuan Zhang,Zhidong Wang,Jun Kong,Chen‐Hua Yan
出处
期刊:Research Square - Research Square
日期:2023-11-16
标识
DOI:10.21203/rs.3.rs-3599648/v1
摘要
Abstract The immune system remodels from the donor to the recipient during allogenic hematopoietic stem cell transplantation (HSCT). However, little is known about the cell profile alterations as donor homeostasis is rebalanced recipient homeostasis following HSCT. We dissected the dynamics of the rebalanced homeostatic immune system in recipients received HLA-matched and haploidentical HSCT. All immune subpopulations observed in donors were successfully restored in recipients with varying levels of abundance. The remodeling of immune homeostasis exhibited different patterns in HLA-matched and haploidentical HSCT, highlighting distinct biases in T cell reconstitution from the central and peripheral pathways. Furthermore, ZNF683 is critical for maintaining the persistence and quiescence of CD8 T-cell in haploidentical HSCT. Our research could serve as a foundation for developing novel strategies to induce immune tolerance.
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