再生医学
自愈水凝胶
生物相容性
组织工程
纳米技术
透明质酸
药物输送
材料科学
生物医学工程
化学
生物化学
工程类
高分子化学
生物
冶金
细胞
遗传学
作者
Chuanfeng An,Hanting Li,Yanqiu Zhao,Zhang Shi-ying,Yuan Zhao,Yujie Zhang,Jianhua Yang,Lijun Zhang,Changle Ren,Yang Zhang,Jia Liu,Huanan Wang
标识
DOI:10.1016/j.ijbiomac.2023.123307
摘要
Hyaluronic acid (HA) is an important type of naturally derived carbohydrate polymer with specific polysaccharide macromolecular structures and multifaceted biological functions, including biocompatibility, low immunogenicity, biodegradability, and bioactivity. Specifically, HA hydrogels in a microscopic scale have been widely used for biomedical applications, such as drug delivery, tissue engineering, and medical cosmetology, considering their superior properties outperforming the more conventional monolithic hydrogels in network homogeneity, degradation profile, permeability, and injectability. Herein, we reviewed the recent progress in the preparation and applications of HA microgels in biomedical fields. We first summarized the fabrication of HA microgels by focusing on the different crosslinking/polymerization schemes for HA gelation and the miniaturized fabrication techniques for producing HA-based microparticles. We then highlighted the use of HA-based microgels for different applications in regenerative medicine, including cartilage repair, bioactive delivery, diagnostic imaging, modular tissue engineering. Finally, we discussed the challenges and future perspectives in bridging the translational gap in the utilization of HA-based microgels in regenerative medicine.
科研通智能强力驱动
Strongly Powered by AbleSci AI