细胞外基质
纤维发生
细胞生物学
牙周纤维
化学
成纤维细胞
生物
医学
牙科
生物化学
纤维
体外
作者
Taishi Komori,Vardit Kram,Sarah L. Perry,Hai Thanh Pham,Priyam Jani,Tina M. Kilts,Koichi Watanabe,Do‐Gyoon Kim,Daniel Martı́n,Marian F. Young
标识
DOI:10.1177/00220345241256306
摘要
The periodontal ligament (PDL) is a fibrillar connective tissue that lies between the alveolar bone and the tooth and is composed of highly specialized extracellular matrix (ECM) molecules and a heterogeneous population of cells that are responsible for collagen formation, immune response, bone formation, and chewing force sensation. Type VI collagen (COL6), a widely distributed ECM molecule, plays a critical role in the structural integrity and mechanical properties of various tissues including muscle, tendon, bone, cartilage, and skin. However, its role in the PDL remains largely unknown. Our study shows that deficiency of COL6 impairs PDL fibrillogenesis and exacerbates tissue destruction in ligature-induced periodontitis (LIP). We found that COL6-deficient mice exhibited increased bone loss and degraded PDL in LIP and that fibroblasts expressing high levels of
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