谵妄
血尿素氮
优势比
医学
内科学
孟德尔随机化
咪唑安定
回顾性队列研究
逻辑回归
重症监护医学
麻醉
肾功能
基因型
化学
生物化学
遗传变异
基因
镇静
作者
Yipeng Fang,Xiaohong Tang,Ying Gao,Hui Xie,Yuehao Shen,Min Peng,Jie Liu,Yunfei Zhang,Yan Cui,Keliang Xie
摘要
ABSTRACT Objective This study investigates the association between blood urea nitrogen (BUN) levels and the risk of delirium in critically ill elderly patients without kidney disease. Methods A retrospective analysis was conducted using data from the MIMIC‐IV database. The relationship between BUN and delirium risk was illustrated through the restricted cubic spline (RCS) method. Patients were stratified by BUN levels and examined for delirium incidence using logistic regression, subgroup analysis, and sensitivity analysis. Mendelian randomization (MR) was employed to explore potential causal relationships. Results The maximum BUN level exhibited the strongest non‐linear positive association with the odds of delirium. Compared to the Q1 group, both the Q3 (23–31 mg/dL) and Q4 (> 31 mg/dL) groups consistently showed increased odds of developing delirium. Subgroup analysis identified a significant interaction between BUN and midazolam, with the association only evident in patients not exposed to midazolam. After adjusting for baseline characteristics, the odds ratio for delirium was found to range from 1.35 to 1.39 in those with BUN levels exceeding 23 mg/dL. However, the MR analysis did not reveal any significant causal relationship (all p > 0.05). Conclusion In conclusion, elevated BUN may be a risk factor for delirium in critically ill elderly patients without renal dysfunction, with this potential link possibly modulated by midazolam exposure.
科研通智能强力驱动
Strongly Powered by AbleSci AI