功能磁共振成像
静息状态功能磁共振成像
血流动力学反应
功能连接
心理学
神经科学
神经影像学
认知心理学
医学
内科学
心率
血压
作者
D. Rangaprakash,Robert Barry,Gopikrishna Deshpande
标识
DOI:10.3389/fnins.2023.934138
摘要
Functional magnetic resonance imaging (fMRI) is an indirect measure of neural activity with the hemodynamic response function (HRF) coupling it with unmeasured neural activity. The HRF, modulated by several non-neural factors, is variable across brain regions, individuals and populations. Yet, a majority of human resting-state fMRI connectivity studies continue to assume a non-variable HRF. In this article, with supportive prior evidence, we argue that HRF variability cannot be ignored as it substantially confounds within-subject connectivity estimates and between-subjects connectivity group differences. We also discuss its clinical relevance with connectivity impairments confounded by HRF aberrations in several disorders. We present limited data on HRF differences between women and men, which resulted in a 15.4% median error in functional connectivity estimates in a group-level comparison. We also discuss the implications of HRF variability for fMRI studies in the spinal cord. There is a need for more dialogue within the community on the HRF confound, and we hope that our article is a catalyst in the process.
科研通智能强力驱动
Strongly Powered by AbleSci AI