苯
二聚体
立体化学
戒指(化学)
化学
苯衍生物
生物化学
化学合成
有机化学
体外
作者
Yong‐Ming Yan,Xing-Hui Bao,Jijun Li,Yanpeng Li,Haoxing Zhang,Yong‐Xian Cheng
标识
DOI:10.1021/acs.jafc.3c04851
摘要
Aspongamide F (1), a novel N-acetyldopamine (NADA) dimer possessing a 6/6/6 ring system, and (±)-aspongamides G (2) and H (3), rare NADA derivatives with fragmented benzene rings, were isolated from Aspongopus chinensis. (±)-Cicadamides C (4) and D (5), the first 1,4-Benzodioxane NADA dimers featuring a seco-benzene system, and (±)-cicadamides E (6) and F (7), the NADA dimers derivatives, were isolated from Periostracum cicadae. The structures of all compounds were elucidated by spectroscopic analyses and computational methods. A plausible biosynthetic pathway for compounds 1–5 was proposed. The biological assay revealed that (+)–4 and (−)–4 exhibit renal protection in a dose-dependent manner.
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