鲍曼不动杆菌
单克隆抗体
微生物学
抗体
吞噬作用
抗菌剂
免疫系统
生物
细菌
病毒学
免疫学
铜绿假单胞菌
遗传学
作者
Xuemei Yang,Ruohan Wei,Han Liu,Tongyao Wei,Ping Zeng,Yan Chu Cheung,Heng Heng,Edward Wai‐Chi Chan,Xuechen Li,Sheng Chen
出处
期刊:ACS central science
[American Chemical Society]
日期:2024-02-07
卷期号:10 (2): 439-446
标识
DOI:10.1021/acscentsci.3c01507
摘要
The therapeutic effects of antibodies include neutralization of pathogens, activation of the host complement system, and facilitation of phagocytosis of pathogens. However, antibody alone has never been shown to exhibit bactericidal activity. In this study, we developed a monoclonal antibody that targets the bacterial cell surface component Pseudaminic acid (Pse). This monoclonal antibody, Pse-MAB1, exhibited direct bactericidal activity on Acinetobacter baumannii strains, even in the absence of the host complements or other immune factors, and was able to confer a protective effect against A. baumannii infections in mice. This study provides new insight into the potential of developing monoclonal antibody-based antimicrobial therapy of multidrug resistant bacterial infections, especially those which occurred among immunocompromised patients.
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