细胞激素风暴
细胞因子
肿瘤坏死因子α
医学
炎症
免疫学
全身给药
免疫系统
白细胞介素6
内科学
生物
体内
生物技术
传染病(医学专业)
疾病
2019年冠状病毒病(COVID-19)
作者
Sheng Chen,Enen Chen,Xiaoling Guan,Junfang Li,Aiping Qin,Chen Wang,Xihua Fu,Chen Huang,Jianhao Li,Yukuan Tang,Minyan Wei,Lingmin Zhang,Jianfen Su
标识
DOI:10.1016/j.colsurfb.2023.113731
摘要
Cytokine storms characterized by excessive secretion of circulating cytokines and immune-cell hyperactivation are life-threatening systemic inflammatory syndromes. The new strategy is in great demand to inhibit the cytokine storm. Here, we designed a type of magnetically controlled nanorobots (MAGICIAN) by fusing neutrophil membranes onto Fe3O4 nanoparticles (Fe3O4NPs). In our study, the receptors of neutrophil membranes were successfully coated to the surface of Fe3O4NPs. The associated membrane functions of neutrophils were highly preserved. MAGICIAN could in vitro neutralize the inflammatory cytokines including interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and interferon γ (IFN-γ). Interestingly, MAGICIAN could be navigated to the liver sites under magnetic control and accelerated the cytokine clearance by the liver. Administration of MAGICIAN could efficiently relieve the inflammation in the acute lung injury mouse model. In addition, MAGICIAN displayed good biosafety in systemic administration. The present study provides a safe and convenient approach for the clearance of cytokine storms, indicating the potential for clinical application in acute lung injury therapy.
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