伤口愈合
细胞外基质
化学
芹菜素
细胞生物学
真皮
血管生成
再生(生物学)
重编程
脂肪组织
生物医学工程
病理
生物化学
外科
医学
癌症研究
生物
细胞
类黄酮
抗氧化剂
作者
Sreelekshmi Sreekumar,Vinu Vijayan,K. P. Gangaraj,Manikantan Syamala Kiran
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2024-02-15
卷期号:7 (3): 1317-1335
标识
DOI:10.1021/acsabm.3c00609
摘要
Wound management in obesity is complicated by excessive exudates from wounded areas, pressure ulcerations due to stacking of the fat layer, and vascular rarefaction. The current study explored the development of biomaterials for reprogramming the altered wound microenvironment under obese conditions. Self-assembled collagen biomatrix with trans and de novo browning activator, apigenin, was fabricated as a soft tissue regenerative wound dressing material. The as-synthesized self-assembled collagen biomatrix exhibited excellent thermal, mechanical, and biological stability with a superior wound exudate absorption capacity. The apigenin self-assembled collagen biomatrix exhibited porous 3-D microstructure that mimicked the extracellular matrix that promoted cell adhesion and proliferation. The apigenin self-assembled collagen multifunctional biomatrix triggered adaptive localized thermogenesis in the subcutaneous fat layer, resulting in the activation of angiogenesis and fibroblast spreading and migration. The in vivo wound healing assay performed in DIO-C57BL6 mice showed faster tissue regeneration within 9 days, with well-defined neo-epidermis, blood vessel formation, thick collagen deposition, minimal inflammation, and significant activation of browning in the subcutaneous adipose layer. This study paves the way forward for the development of specialized regenerative biomatrices that reprogram the obese wound bed for faster tissue regeneration.
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