Association between serum uric acid levels and lung function in the NHANES cohort (2007–2012): A cross‐sectional analysis of a diverse American population

Abstract Background Hyperuricemia has been linked to various health conditions. However, the relationship between uric acid (UA) levels and lung function remains debated. Methods In a cross‐sectional study of 6750 participants aged 20–69 from NHANES, we assessed UA levels and lung function (FVC and FEV1). We conducted regression analyses while adjusting for potential confounders. Results After accounting for factors like age, sex, BMI, smoking, and more, we found a negative association between UA FVC and FEV1. Specifically, for every 0.1 mg/dL increase in UA, FEV1 decreased by 15.265 mL, and FVC decreased by 24.46 mL. No association was observed with FEV1/FVC. Subgroup analyses revealed similar negative correlations among various groups, particularly in non‐Hispanic Black females under 60. Conclusion Serum UA levels are inversely associated with FEV1 and FVC in the American population, with a notable impact on non‐Hispanic Black females under 60.