生物
拟南芥
基因表达
基因
核糖核酸
脱甲基酶
遗传学
基因表达调控
甲基化
DNA甲基化
细胞生物学
表观遗传学
突变体
作者
Ling Wang,Haiyan Zhuang,Wenwen Fan,Xia Zhang,Haihong Dong,Hongxing Yang,Jungnam Cho
标识
DOI:10.1186/s13059-022-02814-8
摘要
Abstract Heat-imposed crop failure is often attributed to reduced thermotolerance of floral tissues; however, the underlying mechanism remains unknown. Here, we demonstrate that m 6 A RNA methylation increases in Arabidopsis flowers and negatively regulates gene expression variability. Stochastic gene expression provides flexibility to cope with environmental stresses. We find that reduced transcriptional fluctuation is associated with compromised activation of heat-responsive genes. Moreover, disruption of an RNA demethylase AtALKBH10B leads to lower gene expression variability, suppression of heat-activated genes, and strong reduction of plant fertility. Our work proposes a novel role for RNA methylation in the bet-hedging strategy of heat stress response.
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