毛皮
病毒包膜
糖蛋白
病毒进入
病毒学
埃博拉病毒
生物
病毒复制
病毒
疱疹病毒糖蛋白B
外域
传染性
细胞生物学
进入抑制剂
受体
生物化学
酶
作者
Changqing Yu,Guosheng Wang,Qiang Liu,Jingbo Zhai,Mengzhou Xue,Qiang Li,Yuanhua Xian,Zheng Chen
标识
DOI:10.1080/22221751.2022.2164742
摘要
Viral envelope glycoproteins are crucial for viral infections. In the process of enveloped viruses budding and release from the producer cells, viral envelope glycoproteins are presented on the viral membrane surface as spikes, promoting the virus's next-round infection of target cells. However, the host cells evolve counteracting mechanisms in the long-term virus-host co-evolutionary processes. For instance, the host cell antiviral factors could potently suppress viral replication by targeting their envelope glycoproteins through multiple channels, including their intracellular synthesis, glycosylation modification, assembly into virions, and binding to target cell receptors. Recently, a group of studies discovered that some host antiviral proteins specifically recognized host proprotein convertase (PC) furin and blocked its cleavage of viral envelope glycoproteins, thus impairing viral infectivity. Here, in this review, we briefly summarize several such host antiviral factors and analyze their roles in reducing furin cleavage of viral envelope glycoproteins, aiming at providing insights for future antiviral studies.
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