生物陶瓷
材料科学
立方氧化锆
生物相容性
生物材料
表面改性
陶瓷
生物医学工程
涂层
植入
纳米技术
复合材料
机械工程
医学
冶金
外科
工程类
作者
Ginny Soon,Belinda Pingguan‐Murphy,Khin Wee Lai,Sheikh A. Akbar
标识
DOI:10.1016/j.ceramint.2016.05.077
摘要
Zirconia is gaining interest as a ceramic biomaterial for implant applications due to its biocompatibility and desirable mechanical properties. At present, zirconia-based ceramic is often seen in the applications of hip replacement and dental implants. This paper briefly reviews different surface modification techniques that have been applied to zirconia such as polishing, sandblasting, etching, biofunctionalization, coating, laser treatment, and ultraviolet light treatment. The cellular response of osteoblast-like cell, osteoblast cell, fibroblast, and epithelial cell to the modified surface is discussed in terms of their adhesion, proliferation, and metabolic activity. The potential of surface modification to make zirconia a successful implant material in the future is highly dependent on the establishment of successful in vitro and in vivo studies. Hence, further effort should be made in order to deepen the understanding of tissue response to the implant and the tissue regeneration process. The review concludes with future prospect of research and further challenges in developing better zirconia bioceramics.
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