[Comparison of two methods of postoperative radiotherapy in anaplastic cerebral oligodendroglioma].

Preliminary results of prospective clinical study--49 adult patients with histologically proven anaplastic oligodendroglioma received postoperative radiotherapy. Patients were randomized to two treatment arms: Conventionally Fractionated Radiotherapy (CFR) and Large Fractionated Radiotherapy (LFR). In CFR group the whole brain was irradiated to the total dose of 50 Gy in 25 fractions over 5 weeks, then a 10 Gy "boost" in 5 fractions was delivered to the site of primary lesion in 5 days. In LFR group there were 3 courses of irradiation separated with one month interval. In each of the two first series the patients received 20 Gy in 5 fractions in five days to the whole brain, and in the third course, 10 Gy "boost" was delivered like in CFR regimen. The tolerance to treatment was good in both groups. Actuarial survival rates 2 and 4 years were 20% and 4% respectively for CFR group, and they were 27% and 0% respectively for LFR.