Cardiovascular action and therapeutic effect of Xinmailong injection for treating heart failure

Xinmailong(XML) injection is a new kind of therapeutic agents for heart failure that came into market in 2006.Its active constituents include polypeptides,nucleosides,and aminofusins.A lot of in vivo and in vitro studies show that XML injection has various effects on cardiovascular activity,such as increasing the free Ca2+ content in myocardial cells,hence enhancing myocardial contractility persistently and gently;dilating coronary arteries to increase coronary flow;inhibiting the myocardial damage induced by oxygen free radicals;declining pulmonary pressure,pulmonary capillary pressure and systemic arterial pressure;correcting neuroendocrine disorders such as increasing calcitonin gene related protein(CGRP) content and inhibiting the secretion and function of endothelin(ET);dilating vessels of kidney to increase the renal blood flow and diuresis;and preventing arhythmia.Clinically,Xinmailong injection is an effective and safe drug for heart failure without obvious side effects,providing the patients with a new optional treatment.