骨骼肌
生物
转录调控
细胞生物学
疾病
神经科学
生物信息学
基因表达调控
医学
转录因子
基因
遗传学
解剖
病理
作者
Kaitlin Weskamp,Bradley B. Olwin,Roy Parker
标识
DOI:10.1016/j.molmed.2020.12.002
摘要
Skeletal muscle formation is a complex process that requires tight spatiotemporal control of key myogenic factors. Emerging evidence suggests that RNA processing is crucial for the regulation of these factors, and that multiple post-transcriptional regulatory pathways work dependently and independently of one another to enable precise control of transcripts throughout muscle development and repair. Moreover, disruption of these pathways is implicated in neuromuscular disease, and the recent development of RNA-mediated therapies shows enormous promise in the treatment of these disorders. We discuss the overlapping post-transcriptional regulatory pathways that mediate muscle development, how these pathways are disrupted in neuromuscular disorders, and advances in RNA-mediated therapies that present a novel approach to the treatment of these diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI