Relationship between mitophagy and browning of white adipose

As we all known, obesity is associated with many diseases. Browning of white adipose, as a new way for the treatment of obesity, has received the widespread attention. During the process of white-to-brown, the numbers and function of mitochondria have been significantly changed. Mitophagy is an important way, which changes the number of mitochondria and controls the quality of mitochondria. Recently, some studies have revealed that the inhibition of mitophagy could prevent adipose-derived stem cells from differentiating into white adipocyte and promote the transformation of mature white adipocyte into beige adipocyte. However, the relationship between mitophagy and browning process is still unclear, which needs further study. Key words: Mitophagy; Browning of white adipose; Obesity