Dynamic covalent constructed self-healing hydrogel for sequential delivery of antibacterial agent and growth factor in wound healing

自愈水凝胶 伤口愈合 明胶 肿胀 的 生物医学工程 自愈 化学 药物输送 共价键 材料科学 高分子化学 外科 有机化学 复合材料 医学 病理 替代医学
作者
Mingmao Chen,Jia Tian,Yan Liu,Huấn Cao,Ruyue Li,Jianhua Wang,Jiulin Wu,Qiqing Zhang
出处
期刊:Chemical Engineering Journal [Elsevier]
卷期号:373: 413-424 被引量:210
标识
DOI:10.1016/j.cej.2019.05.043
摘要

The conventional injectable hydrogels as wound dressing materials frequently encounter bacterial infection and lack self-healing ability. Besides, the hydrogels injected into the irregular wound sites are easily damaged by external forces, which further hinder wound healing. To make up for these deficiencies, we developed a novel hydrogel with the unique properties including dynamic covalent based self-healing, antibacterial and sequential drug release. This injectable and self-healing hydrogel was constructed via the dynamic reaction of aminated gelatin (NGel), adipic acid dihydrazide (ADH) and oxidized dextran (ODex). After injection or damage, the broken hydrogel pieces performed excellent self-healing capability to generate an integral hydrogel owing to dynamic imine and acylhydrazone bonds. Meanwhile, b[email protected] microspheres and chlorhexidine acetate (CHA) were embedded into the hydrogels. This [email protected]/CHA/hydrogel presented a good biodegradability, and it could retain the morphological stability after swelling. Moreover, [email protected]/CHA/hydrogels achieved the sequential release of CHA and bFGF during the drug release assay. When topically applied onto the wound skin of rats, the hydrogels can effectively prevent infection at the early stages due to the rapid release of CHA, then further accelerate cell proliferation and wound healing through the sustained release of bFGF. These results indicate that the proposed self-healing hydrogel with sequential release properties is a highly promising dressing material for wound healing.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
不必要再讨论适合与否完成签到,获得积分0
1秒前
隐形之玉发布了新的文献求助10
3秒前
3秒前
kokodayour完成签到,获得积分10
4秒前
丘比特应助冷酷云朵采纳,获得10
9秒前
9秒前
10秒前
wl5289完成签到,获得积分10
12秒前
13秒前
wl5289发布了新的文献求助10
15秒前
18秒前
Ann发布了新的文献求助10
19秒前
科研66666完成签到 ,获得积分10
21秒前
受伤的冰海完成签到 ,获得积分10
22秒前
没有昵称完成签到,获得积分10
24秒前
future完成签到 ,获得积分10
31秒前
喂喂喂完成签到 ,获得积分10
34秒前
默默的大腚完成签到 ,获得积分10
34秒前
贾舒涵完成签到,获得积分10
37秒前
Jason完成签到 ,获得积分20
37秒前
38秒前
斯文败类应助云朵上的鱼采纳,获得10
39秒前
destiny完成签到 ,获得积分10
40秒前
41秒前
彭笑笑完成签到 ,获得积分10
42秒前
xjcy应助smm采纳,获得10
44秒前
ss_hHe发布了新的文献求助10
44秒前
46秒前
yiheng发布了新的文献求助10
47秒前
51秒前
liudi123456完成签到,获得积分10
52秒前
53秒前
53秒前
yiheng完成签到,获得积分10
54秒前
清爽尔安发布了新的文献求助10
57秒前
小王完成签到,获得积分10
59秒前
zhangxin发布了新的文献求助30
1分钟前
1分钟前
1分钟前
云朵上的鱼完成签到,获得积分10
1分钟前
高分求助中
Sustainability in Tides Chemistry 2800
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Handbook of Qualitative Cross-Cultural Research Methods 600
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3137561
求助须知:如何正确求助?哪些是违规求助? 2788520
关于积分的说明 7787276
捐赠科研通 2444861
什么是DOI,文献DOI怎么找? 1300093
科研通“疑难数据库(出版商)”最低求助积分说明 625796
版权声明 601023