液体活检
循环肿瘤细胞
医学
微泡
活检
胎儿游离DNA
个性化医疗
病理
肿瘤细胞
小RNA
癌症
癌症研究
生物信息学
内科学
基因
转移
生物
胎儿
生物化学
产前诊断
怀孕
遗传学
作者
Susana Junqueira-Neto,Ines Batista,José Luis Costa,Sonia A. Melo
出处
期刊:Acta Cytologica
[Karger Publishers]
日期:2019-01-01
卷期号:63 (6): 479-488
被引量:38
摘要
Liquid biopsy represents the analysis of tumor-derived material in the blood and other body fluids of cancer patients. This portrays a minimally invasive detection tool for molecular biomarkers. Liquid biopsy has emerged as a complementary or alternative method to surgical biopsy. This non-invasive detection tool overcomes the recurrent problems in the clinical assessment of tumors that stem from the lack of accessibility to the tumor tissue and its clonal heterogeneity. Moreover, body fluid-derived components have shown to reflect the genetic profile of both primary and metastatic lesions and provide a real-time monitoring of tumor dynamics, representing a great promise for personalized medicine. This review will highlight the latest breakthroughs and the current applications of several tumor-derived biomarkers that can be found in body fluids. The authors will focus on tumor-derived exosomes, tumor-educated platelets, and circulating tumor miRNAs and mRNAs, and how these can be used for tumor detection.
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