传出细胞增多
吞噬细胞
吞噬作用
梅尔特克
巨噬细胞
单核吞噬细胞系统
细胞生物学
生物
背景(考古学)
免疫学
小RNA
炎症
泡沫电池
平衡
信号转导
体外
生物化学
基因
受体酪氨酸激酶
古生物学
作者
Amir Tajbakhsh,Vanessa Bianconi,Matteo Pirro,Seyed Mohammad Gheibi Hayat,Thomas P. Johnston,Amirhossein Sahebkar
标识
DOI:10.1016/j.tem.2019.07.006
摘要
There is evidence of the critical role of efferocytosis, the clearance of apoptotic cells (ACs) by phagocytes, in vascular cell homeostasis and protection against atherosclerosis. Specific microRNAs (miRs) can regulate atherogenesis by controlling the accumulation of professional phagocytes (e.g., macrophages) and nonprofessional phagocytes (i.e., neighboring tissue cells with the ability to acquire a macrophage-like phenotype) within the arterial wall, the differentiation of phagocytes into foam cells, the efferocytosis of apoptotic foam cells by phagocytes, and the phagocyte-mediated inflammatory response. A better understanding of the mechanisms involved in miR-regulated phagocyte function might lead to novel therapeutic antiatherosclerotic strategies. In this review, we try to shed light on the relationship between miRs and cellular players in the process of efferocytosis in the context of atherosclerotic plaque and their potential as molecular targets for novel antiatherosclerotic therapies.
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