安普克
自噬
神经保护
神经营养因子
海马结构
海马体
AMP活化蛋白激酶
内分泌学
内科学
蛋白激酶A
认知功能衰退
活性氧
丙二醛
细胞凋亡
化学
细胞生物学
生物
医学
氧化应激
激酶
生物化学
受体
疾病
痴呆
作者
Juan Zhuang,Jun Lü,Xin Wang,Xinfeng Wang,Weicheng Hu,Fashui Hong,Xiangxiang Zhao,Yuan‐Lin Zheng
标识
DOI:10.1016/j.jnutbio.2018.10.015
摘要
Prevention of obesity-induced cognitive decline is an important public health goal. Purple sweet potato color (PSPC), a class of naturally occurring anthocyanins, has beneficial potentials including antioxidant and neuroprotective activity. Evidence shows that anthocyanins can activate AMP-activated protein kinase (AMPK), a critical mediator of autophagy induction. This study investigated whether PSPC could improve cognitive function through regulating AMPK/autophagy signaling in HFD-fed obese mice. Our results showed that PSPC significantly ameliorated obesity, peripheral insulin resistance and memory impairment in HFD-fed mice. Moreover, enhanced autophagy was observed, along with the decreased levels of protein carbonyls, malondialdehyde and reactive oxygen species (ROS) in the hippocampus of HFD-fed mice due to PSPC administration. PSPC also promoted hippocampal brain-derived neurotrophic factor (BDNF) expression and neuron survival in HFD-fed mouse. These improvements were mediated, at least in part, by the activation of AMPK, which was confirmed by metformin treatment. It is concluded that PSPC has great potential to improve cognitive function in HFD-fed mice via AMPK activation that restores autophagy and protects against hippocampal apoptosis.
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