OSA, Short Sleep Duration, and Their Interactions With Sleepiness and Cardiometabolic Risk Factors in Adults

医学 活动记录 血脂异常 阻塞性睡眠呼吸暂停 混淆 体质指数 队列 内科学 肥胖 物理疗法 睡眠(系统调用) 白天过度嗜睡 腰围 睡眠障碍 失眠症 精神科 昼夜节律 操作系统 计算机科学
作者
Luciano F. Drager,Ronaldo B. Santos,Wagner A. Silva,Barbara K. Parise,Soraya Giatti,Aline N. Aielo,Samilly Evangelista Souza,Sofia F. Furlan,Geraldo Lorenzi‐Filho,Paulo A Lotufo,Isabela M. Benseñor
出处
期刊:Chest [Elsevier BV]
卷期号:155 (6): 1190-1198 被引量:56
标识
DOI:10.1016/j.chest.2018.12.003
摘要

OSA and short sleep duration (SSD) are frequently associated with daytime symptoms and cardiometabolic deregulation. However, the vast majority of studies addressing OSA have not evaluated SSD, and vice versa. Our aim was to evaluate the association of OSA, SSD, and their interactions with sleepiness and cardiometabolic risk factors in a large cohort of adults.Consecutive subjects from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) participated in clinical evaluations, sleep questionnaires, home sleep monitoring, and actigraphy. OSA was defined as an apnea-hypopnea index ≥ 15 events/hour. SSD was defined by a mean sleep duration < 6 h.Data from 2,064 participants were used in the final analysis (42.8% male; mean age, 49 ± 8 years). The overall frequency of OSA and SSD were 32.9% and 27.2%, respectively. Following an adjustment for multiple confounding factors, excessive daytime sleepiness was independently associated with SSD (OR, 1.448; 95% CI, 1.172-1.790) but not with OSA (OR, 1.107; 95% CI, 0.888-1.380). The SSD interaction with OSA was not significant. Prevalent obesity (OR, 3.894; 95% CI, 3.077-4.928), hypertension (OR, 1.314; 95% CI, 1.035-1.667), and dyslipidemia (OR, 1.251; 95% CI, 1.006-1.555) were independently associated with OSA but not with SSD. Similarly, the interactions of OSA with SSD were not significant. An additional analysis using < 5 h for SSD or continuous sleep duration did not change the lack of association with the cardiometabolic risk factors.Objective SSD but not OSA was independently associated with daytime sleepiness. By contrast, OSA, but not SSD, was independently associated with obesity, hypertension, and dyslipidemia.
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