医学
宫颈上皮内瘤变
宫颈癌
阴道镜检查
细胞学
妇科
内科学
宫颈炎
癌症
胃肠病学
肿瘤科
病理
作者
Yuehui Su,Yujie Tang,Ting Zhang,Yue Xu,Yingcui Zhang,Yan Shen,Lihong Qin,Luoman Zhang,Lili Cao,Yingying Zhou,Yu‐Ligh Liou,Mengzhen Zhang
出处
期刊:Future Oncology
[Future Medicine]
日期:2022-06-27
卷期号:18 (23): 2583-2592
被引量:5
标识
DOI:10.2217/fon-2021-1625
摘要
Aim: To explore the appropriate triage methods for women infected with high-risk human papillomavirus (hrHPV). Materials & methods: A total of 424 out of 872 hrHPV-infected women were divided into cervicitis (n = 123), cervical intraepithelial neoplasia grade 1 (CIN1; n = 89), CIN2 (n = 72), CIN3 (n = 87) and cervical cancer (n = 53) groups. Results: The sensitivity/specificity of ZNF582m, PAX1m and liquid-based cytology (LBC) for hrHPV-infected women with transformation zone 3 CIN3+ was 83.9/93.1, 77.4/90.6 and 80.6/58.5%, respectively. The ZNF582m/PAX1m test had a higher specificity than LBC (p < 0.001) and similar sensitivity to that observed for LBC (p > 0.05). ZNF582m/PAX1m improved the positive predictive value of CIN3+ (64.7/60.0%) in low-grade LBC (negative predictive value: 91.7/88.7%). Conclusion:ZNF582m was superior to PAX1m and LBC tests in detecting CIN3+ in hrHPV-infected women.Human papillomavirus (HPV) testing is the main method for cervical cancer screening. Although most HPV infections are transient and can be cleared by the body, persistent infection with HPV can lead to cervical cancer. In this study, 424 HPV-infected women were divided into normal, cervical intraepithelial neoplasia grade 1 (CIN1), CIN2, CIN3 and cervical cancer groups according to the grade of cervical lesion (low to high). Women with CIN3 or cervical cancer need treatment. ZNF582m, PAX1m and liquid-based cytology detected 83.9, 77.4 and 80.6% of women with CIN3+ and 93.1, 90.6 and 58.5% of women without CIN3+. However, the ZNF582m test was superior to the PAX1m and liquid-based cytology tests.
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