纳米笼
铁蛋白
纳米载体
化学
生物物理学
磷酸盐
半胱氨酸蛋白酶
姜黄素
生物化学
蛋白酵素
纳米技术
药物输送
材料科学
有机化学
生物
酶
催化作用
作者
Hai Chen,Liang Ma,Hongjie Dai,Yu Fu,Xueer Han,Yuhao Zhang
出处
期刊:Food Chemistry
[Elsevier]
日期:2022-07-16
卷期号:397: 133680-133680
被引量:5
标识
DOI:10.1016/j.foodchem.2022.133680
摘要
Ferritin nanocages are promising nanocarriers for food bioactive compound delivery, but gastrointestinal barriers including disassociation by environmental acidity, degradation by protease, pose great challenges for cargo delivery. Herein, a self-protective ferritin that can cross gastrointestinal barriers is prepared through phosphorylation modification at 37 °C for 4 h. The results showed that the conjugation of phosphate group facilitates an acidic pI shift of ferritin from ∼5.0 to ∼4.0, allowing fast aggregation and precipitation in an intact spherical form rather than disassociation into subunits in acidic environments. Meanwhile, after incubation at simulated gastric juice for 30 min, almost 80 % STP-MjFer is retained, thus, the aggregation state and phosphate layers can improve its digestive stability. Besides, curcumin can be encapsulated within its cavity and the retention rate is ∼ 9 times higher than that of MjFer nanocage in simulated gastrointestinal fluid. Overall, the self-protective ferritin nanocarrier displays great potential for cargo delivery in food science.
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