间充质干细胞
促炎细胞因子
肥大细胞
肌腱病
医学
伤害
干细胞
细胞因子
炎症
病理
细胞生物学
生物
免疫学
内科学
肌腱
受体
作者
Renzhi Gao,Teng Ye,Zhaochen Zhu,Qing Li,Qian Zhang,Ji Yuan,Bizeng Zhao,Zongping Xie,Yang Wang
出处
期刊:Nanomedicine
日期:2022-04-01
卷期号:17 (8): 513-529
被引量:20
标识
DOI:10.2217/nnm-2022-0036
摘要
Aim: This study aimed to explore the effect of small extracellular vesicles from induced pluripotent stem cell-derived mesenchymal stem cells (iMSC-sEVs) on acute pain and investigate the underlying mechanisms. Materials & methods: The pathology of tendons was accessed by hematoxylin and eosin staining, immunohistochemical and immunofluorescent staining. The pain degree was measured by pain-related behaviors. In vitro, we performed β-hexosaminidase release assay, RT-qPCR, toluidine blue staining, ELISA and RNA sequencing. Results: iMSC-sEVs effectively alleviated acute pain in tendinopathy as well as inhibiting activated mast cell infiltration and interactions with nerve fibers in vivo. In vitro, iMSC-sEVs reduced the degranulation of mast cells and the expression of proinflammatory cytokines and genes involved in the HIF-1 signaling pathway. Conclusion: This study demonstrated that iMSC-sEVs relieved tendinopathy-related pain through inhibiting mast cell activation via the HIF-1 signaling pathway.
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