Serum inflammatory markers and their associations with white matter integrity of the corpus callosum in schizophrenia patients and healthy controls

胼胝体 精神分裂症(面向对象编程) 亚临床感染 白质 医学 部分各向异性 内科学 炎症 神经影像学 白细胞介素 发病机制 白细胞介素6 病理 胃肠病学 细胞因子 磁共振成像 精神科 放射科
作者
Anna Michalczyk,Ernest Tyburski,Piotr Podwalski,Katarzyna Waszczuk,Krzysztof Rudkowski,Jolanta Kucharska–Mazur,Monika Mak,Katarzyna Rek-Owodziń,Piotr Plichta,Maksymilian Bielecki,Wojciech Andrusewicz,Elżbieta Cecerska‐Heryć,Agnieszka Samochowiec,Błażej Misiak,Leszek Sagan,Jerzy Samochowiec
出处
期刊:Progress in Neuro-psychopharmacology & Biological Psychiatry [Elsevier]
卷期号:116: 110510-110510 被引量:16
标识
DOI:10.1016/j.pnpbp.2022.110510
摘要

Schizophrenia is associated with disrupted integrity of white matter microstructure of a variety of brain regions, especially the corpus callosum (CC). Chronic subclinical inflammation is considered to be one of the factors involved in the pathogenesis of this disease, and increased levels of peripheral inflammatory markers are often observed in schizophrenia patients. Therefore, we decided to investigate whether the integrity of the corpus callosum is correlated with levels of these markers. A total of 50 patients with stable chronic schizophrenia (SCH) and 30 controls (CON) were enrolled in the study. All participants underwent psychiatric evaluation, neuroimaging, and blood sampling including the measurement of serum concentrations of interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL - 10), tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), and C-reactive protein (CRP). Additional potentially related factors, such as age, gender, BMI, smoking, disease duration, and treatment were included in the analysis. Significantly higher IL-6 and IFN-γ levels were observed in SCH compared to CON. In SCH, IFN-γ was positively correlated with mean diffusivity of region 2 of the CC. In CON, IL-6 was inversely correlated with fractional anisotropy of region 1 of the CC. These results support the potential influence of peripheral inflammatory markers on the integrity of the CC in schizophrenia, but require verification in longitudinal studies.
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