Serum inflammatory markers and their associations with white matter integrity of the corpus callosum in schizophrenia patients and healthy controls

胼胝体 精神分裂症(面向对象编程) 亚临床感染 白质 医学 部分各向异性 内科学 炎症 神经影像学 白细胞介素 发病机制 白细胞介素6 病理 胃肠病学 细胞因子 磁共振成像 精神科 放射科
作者
Anna Michalczyk,Ernest Tyburski,Piotr Podwalski,Katarzyna Waszczuk,Krzysztof Rudkowski,Jolanta Kucharska–Mazur,Monika Mak,Katarzyna Rek-Owodziń,Piotr Plichta,Maksymilian Bielecki,Wojciech Andrusewicz,Elżbieta Cecerska‐Heryć,Agnieszka Samochowiec,Błażej Misiak,Leszek Sagan,Jerzy Samochowiec
出处
期刊:Progress in Neuro-psychopharmacology & Biological Psychiatry [Elsevier]
卷期号:116: 110510-110510 被引量:16
标识
DOI:10.1016/j.pnpbp.2022.110510
摘要

Schizophrenia is associated with disrupted integrity of white matter microstructure of a variety of brain regions, especially the corpus callosum (CC). Chronic subclinical inflammation is considered to be one of the factors involved in the pathogenesis of this disease, and increased levels of peripheral inflammatory markers are often observed in schizophrenia patients. Therefore, we decided to investigate whether the integrity of the corpus callosum is correlated with levels of these markers. A total of 50 patients with stable chronic schizophrenia (SCH) and 30 controls (CON) were enrolled in the study. All participants underwent psychiatric evaluation, neuroimaging, and blood sampling including the measurement of serum concentrations of interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL - 10), tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), and C-reactive protein (CRP). Additional potentially related factors, such as age, gender, BMI, smoking, disease duration, and treatment were included in the analysis. Significantly higher IL-6 and IFN-γ levels were observed in SCH compared to CON. In SCH, IFN-γ was positively correlated with mean diffusivity of region 2 of the CC. In CON, IL-6 was inversely correlated with fractional anisotropy of region 1 of the CC. These results support the potential influence of peripheral inflammatory markers on the integrity of the CC in schizophrenia, but require verification in longitudinal studies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
yearluren完成签到,获得积分10
1秒前
刘慧12发布了新的文献求助10
2秒前
Jasper应助solar@2030采纳,获得10
2秒前
John_sdu完成签到,获得积分10
2秒前
养恩应助yuhuihui采纳,获得10
2秒前
韩十四发布了新的文献求助10
3秒前
火星上的菲鹰应助aaaa采纳,获得10
3秒前
充电宝应助王哪跑12采纳,获得10
5秒前
外向的跳跳糖完成签到,获得积分10
6秒前
vicky完成签到,获得积分10
6秒前
乐观的小鸡完成签到 ,获得积分10
7秒前
ludens完成签到,获得积分10
8秒前
收费完成签到,获得积分20
9秒前
10秒前
彦子完成签到 ,获得积分10
11秒前
小蘑菇应助ssy采纳,获得10
11秒前
11秒前
亚亚吖完成签到 ,获得积分10
12秒前
12秒前
牧子完成签到,获得积分10
14秒前
14秒前
15秒前
Nofear发布了新的文献求助10
15秒前
solar@2030发布了新的文献求助10
16秒前
王哪跑12发布了新的文献求助10
17秒前
18秒前
科研通AI2S应助雪白起眸采纳,获得10
18秒前
牛牛完成签到,获得积分10
19秒前
3MB完成签到 ,获得积分10
19秒前
20秒前
20秒前
飞快的鱼发布了新的文献求助10
21秒前
南南完成签到,获得积分10
21秒前
飘逸怜菡完成签到,获得积分10
21秒前
沙洲发布了新的文献求助10
22秒前
鲸鱼完成签到,获得积分10
22秒前
22秒前
彩色黑米完成签到 ,获得积分10
23秒前
NexusExplorer应助刘慧12采纳,获得10
24秒前
24秒前
高分求助中
Comparative Anatomy of the Vertebrates 9th 3000
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3572057
求助须知:如何正确求助?哪些是违规求助? 3142380
关于积分的说明 9447329
捐赠科研通 2843772
什么是DOI,文献DOI怎么找? 1563095
邀请新用户注册赠送积分活动 731568
科研通“疑难数据库(出版商)”最低求助积分说明 718570