化学
香豆素
血管生成
脐静脉
内皮干细胞
化学合成
人脐静脉内皮细胞
细胞培养
癌细胞
体外
立体化学
细胞生长
结构-活动关系
生物化学
药理学
癌症
组合化学
癌症研究
有机化学
生物
遗传学
作者
Seokjoon Lee,K. Sivakumar,Woon‐Seob Shin,Fang Xie,Qian Wang
标识
DOI:10.1016/j.bmcl.2006.06.007
摘要
A series of 7-diethylaminocoumarin compounds were synthesized and the cytotoxicities were tested against human umbilical vein endothelial cell (HUVEC) and some cancer cells. We found that the introduction of cyano groups at the 4-position will promote the bioactivity. In particular, compounds 9 and 10 strongly inhibited the proliferation of various cancer cell lines, and 12 and 15 showed a high selectivity for HUVEC. Therefore, these coumarin molecules can be utilized as lead compounds to develop potential nontoxic angiogenesis inhibitors and small molecular ligands to target HUVEC.
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