头孢哌酮
头孢他啶
头孢匹罗
头孢菌素
医学
头孢噻肟
头孢唑肟
头孢曲松
微生物学
铜绿假单胞菌
肺炎克雷伯菌
阿兹屈南
抗生素
亚胺培南
抗生素耐药性
生物
细菌
大肠杆菌
遗传学
基因
生物化学
标识
DOI:10.1016/s0891-5520(20)30291-9
摘要
The third generation cephalosporins demonstrate greater potency, broader antibacterial spectrum, and more favorable pharmacologic characteristics than other cephalosporins. The majority of strains of E. coli, Klebsiella pneumoniae, and Proteus are susceptible, including strains resistant to aminoglycosides, anti-Pseudomonas penicillins, and other cephalosporins. Pseudomonas aeruginosa is susceptible to a subgroup of third generation agents including ceftazidime, cefoperazone, and the experimental agents cefpirome and cefpiramide. Penetration into the cerebrospinal fluid is excellent especially for cefotaxime, ceftazidime, ceftriaxone, and ceftizoxime. These agents are safe, sharing most of the known toxicities of other beta-lactam compounds. Their greatest use is in the therapy of difficult to treat gram-negative bacterial infections, including meningitis, nosocomial infections, and infections caused by Pseudomonas aeruginosa.
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