化学
糖基化
全合成
衍生工具(金融)
糖
立体化学
有机化学
生物化学
金融经济学
经济
作者
Shunichi Kusumi,Satoshi Tomono,Shunsuke Okuzawa,Erika Kaneko,Takashi Ueda,Kaname Sasaki,Daisuke Takahashi,Kazunobu Toshima
摘要
The first total synthesis of vineomycin B2 (1) has been accomplished. The aglycon segment, a vineomycinone B2 derivative, and the glycon segment, an α-L-acurosyl-L-rhodinose derivative, were prepared via C-glycosylation using an unprotected sugar and powerful chemoselective O-glycosylation using a 2,3-unsaturated sugar, respectively, as the key steps. Furthermore, effective and simultaneous introduction of the two glycon moieties to the aglycon part by concentration-controlled glycosylation led to the total synthesis of 1.
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