脂质Ⅱ
糖肽
镧系元素
抗生素
细胞壁
糖肽抗生素
抗菌剂
细菌细胞结构
生物合成
万古霉素
细胞
化学
细菌
生物化学
药品
抗菌肽
微生物学
生物
肽聚糖
药理学
酶
乳酸链球菌素
金黄色葡萄球菌
遗传学
作者
Tanja Schneider,Hans-Georg Sahl
出处
期刊:PubMed
日期:2010-02-01
卷期号:11 (2): 157-64
被引量:20
摘要
Bacterial cell wall biosynthesis represents an antibiotic target pathway for therapeutic intervention. An increasing number of natural antibiotic compounds have been demonstrated to inhibit the membrane-associated steps of cell wall biosynthesis by targeting bactoprenol-mediated precursor cycling, particularly at the stage of the completed building block Lipid II. These antibiotic compounds belong to various chemical classes including glycopeptides, lipopeptides and lipodepsipeptides, and lantibiotics and other antimicrobial peptides. The clinical success of vancomycin in the treatment of multiresistant Gram-positive bacteria has stimulated further development of glycopeptide antibiotics and research of other Lipid II-binding compounds. The state-of-the-art in the targeting of cell wall precursors is summarized in this review.
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