Proton beam therapy for extrahepatic biliary tract cancer: Analysis with prospective multi-institutional patients’ registration database, Proton-Net

医学 质子疗法 质子 前瞻性队列研究 胆道 内科学 肿瘤科 放射科 胃肠病学 放射治疗 核物理学 物理
作者
Hideya Yamazaki,Kei Shibuya,Takuya Kimoto,Motohisa Suzuki,Masao Murakami,Kazuki Terashima,Tomoaki Okimoto,Takashi Iizumi,Hideyuki Sakurai,Masaru Wakatsuki,Осаму Сузукі,Norio Katoh,Takeshi Arimura,Takashi Ogino,M. Takagi,Masayuki Araya,Takahiro Waki,Sae Matsumoto,Hiroyuki Ogino,Takumi Fukumoto,Masayuki Ohtsuka
出处
期刊:Clinical and Translational Radiation Oncology [Elsevier BV]
卷期号:41: 100634-100634 被引量:2
标识
DOI:10.1016/j.ctro.2023.100634
摘要

To examine the role of proton beam therapy (PBT) in the treatment of extrahepatic biliary tract cancer (EBC).We analyzed the data accumulated in the Proton-Net database, which prospectively registered all individual patient data treated with PBT in all Japanese proton institutions from May 2016 to June 2019. The primary endpoint was overall survival (OS), and the secondary endpoints were local control (LC), progression-free survival (PFS), and toxicity.Ninety-three patients with unresectable and/or recurrent EBC were treated with PBT using a median prescribed dose of 67.5 Gy (RBE) (range, 50-72.6 Gy) in 25 (22-30 fractions). With a median follow-up of 16.3 months, the median survival time was 20.1 months and the 2-year OS was 37.8%. Two-year PFS and LC rates were 20.6% and 66.5%, respectively. Poor liver function (Child-Pugh B, C), a narrower distance between the tumor and digestive tract (2 cm >), and a larger tumor diameter (2 cm <) were identified as poor prognostic factors for OS. PBT-related grade 3 ≤ acute and late adverse events occurred in 5.4% and 4.3% of patients, respectively, including one gastrointestinal late toxicity (duodenal ulcer).This is the largest prospectively accumulated series of PBT for EBC, and PBT showed favorable outcomes with acceptable toxicity profiles.
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