姜黄素
背景(考古学)
免疫系统
药理学
转移
多酚
癌症治疗
医学
癌症
计算生物学
癌症研究
化学
生物信息学
生物
免疫学
生物化学
抗氧化剂
内科学
古生物学
作者
Petr Dytrych,Zdeněk Kejík,Jan Hajduch,Robert Kaplánek,Kateřina Veselá,Kateřina Kučnirová,Markéta Skaličková,Anna Venhauerová,David Hoskovec,Pavel Martásek,Milan Jakubek
标识
DOI:10.1016/j.biopha.2023.114758
摘要
Treatment of metastatic cancer is one of the biggest challenges in anticancer therapy. Curcumin is interesting nature polyphenolic compound with unique biological and medicinal effects, including repression of metastases. High impact studies imply that curcumin can modulate the immune system, independently target various metastatic signalling pathways, and repress migration and invasiveness of cancer cells. This review discusses the potential of curcumin as an antimetastatic agent and describes potential mechanisms of its antimetastatic activity. In addition, possible strategies (curcumin formulation, optimization of the method of administration and modification of its structure motif) to overcome its limitation such as low solubility and bioactivity are also presented. These strategies are discussed in the context of clinical trials and relevant biological studies.
科研通智能强力驱动
Strongly Powered by AbleSci AI