表位
癌症研究
CD8型
生物
肿瘤浸润淋巴细胞
免疫疗法
抗原
转移
体内
免疫学
免疫系统
癌症
遗传学
作者
Weida Lu,Ye Zhang,Ruixin Wang,Shuai Liu,Jing Luo,Yunfei Ma,Hao Wang,Ye Liu,Yun Chen
出处
期刊:Biomaterials
[Elsevier]
日期:2023-11-01
卷期号:302: 122297-122297
标识
DOI:10.1016/j.biomaterials.2023.122297
摘要
The dysfunction of tumor infiltrating lymphocytes (TILs) directly correlates with out of control of tumor growth and metastasis. New approaches and insightful clarity for rescuing TILs dysfunction are urgently needed. Here, we design two heterogenous antigens based on MHC-I epitope and MHC-II epitope from tumor, and assemble heterogenous antigens by electrostatic interactions and π-π stacking into heteroantigen-assembled nanovaccine (HANV). HANV not only significantly increases the abundance of CD8+ and CD4+ TILs, but also elicits stronger polyfunctionality of CD8+ and CD4+ TILs in vivo. Enhanced polyfunctionality of CD8+ and CD4+ TILs positively correlate to suppression of tumor growth and metastasis in melanoma-bearing mouse models. We also validate that nucleotide-binding oligomerization domain-containing protein 2 (NOD2) dominantly enhances anti-tumor capacity of TILs in a temporal immunoregulation manner. This work presents a new insight in developing HANV as a rational strategy to shape TILs polyfunctionality for tumor growth and metastasis.
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