医学
欧洲联盟
职业暴露
生物标志物
柴油机排气
内科学
毒理
环境卫生
化学
柴油
生物化学
有机化学
生物
业务
经济政策
作者
Jason Y.Y. Wong,Batel Blechter,Bryan A. Bassig,Yufei Dai,Roel Vermeulen,Wei Hu,Mohammad L. Rahman,Huawei Duan,Yong Niu,George S. Downward,Shuguang Leng,Bu‐Tian Ji,Wei Fu,Jianing Xu,Kees Meliefste,Baosen Zhou,Jincai Yang,Dianzhi Ren,Meng Ye,Xiaowei Jia,Tao Meng,Bin Peng,H. Dean Hosgood,Nathaniel Rothman,Debra T. Silverman,Yuxin Zheng,Qing Lan
出处
期刊:Occupational and Environmental Medicine
[BMJ]
日期:2023-03-27
卷期号:80 (5): 260-267
标识
DOI:10.1136/oemed-2022-108719
摘要
We previously found that occupational exposure to diesel engine exhaust (DEE) was associated with alterations to 19 biomarkers that potentially reflect the mechanisms of carcinogenesis. Whether DEE is associated with biological alterations at concentrations under existing or recommended occupational exposure limits (OELs) is unclear.In a cross-sectional study of 54 factory workers exposed long-term to DEE and 55 unexposed controls, we reanalysed the 19 previously identified biomarkers. Multivariable linear regression was used to compare biomarker levels between DEE-exposed versus unexposed subjects and to assess elemental carbon (EC) exposure-response relationships, adjusted for age and smoking status. We analysed each biomarker at EC concentrations below the US Mine Safety and Health Administration (MSHA) OEL (<106 µg/m3), below the European Union (EU) OEL (<50 µg/m3) and below the American Conference of Governmental Industrial Hygienists (ACGIH) recommendation (<20 µg/m3).Below the MSHA OEL, 17 biomarkers were altered between DEE-exposed workers and unexposed controls. Below the EU OEL, DEE-exposed workers had elevated lymphocytes (p=9E-03, false discovery rate (FDR)=0.04), CD4+ count (p=0.02, FDR=0.05), CD8+ count (p=5E-03, FDR=0.03) and miR-92a-3p (p=0.02, FDR=0.05), and nasal turbinate gene expression (first principal component: p=1E-06, FDR=2E-05), as well as decreased C-reactive protein (p=0.02, FDR=0.05), macrophage inflammatory protein-1β (p=0.04, FDR=0.09), miR-423-3p (p=0.04, FDR=0.09) and miR-122-5p (p=2E-03, FDR=0.02). Even at EC concentrations under the ACGIH recommendation, we found some evidence of exposure-response relationships for miR-423-3p (ptrend=0.01, FDR=0.19) and gene expression (ptrend=0.02, FDR=0.19).DEE exposure under existing or recommended OELs may be associated with biomarkers reflective of cancer-related processes, including inflammatory/immune response.