细胞毒性
真菌
青霉属
EC50型
IC50型
海洋真菌
抑制性突触后电位
立体化学
化学
生物
生物化学
体外
植物
神经科学
作者
You‐Jia Hao,Zheng‐Biao Zou,Ming‐Min Xie,Yong Zhang,Lin Xu,Haoyu Yu,Huabin Ma,Xian‐Wen Yang
出处
期刊:Marine Drugs
[MDPI AG]
日期:2023-04-10
卷期号:21 (4): 234-234
被引量:10
摘要
Two new xanthones (1 and 2) were isolated from the deep-sea-derived fungus Penicillium sp. MCCC 3A00126 along with 34 known compounds (3-36). The structures of the new compounds were established by spectroscopic data. The absolute configuration of 1 was validated by comparison of experimental and calculated ECD spectra. All isolated compounds were evaluated for cytotoxicity and ferroptosis inhibitory activities. Compounds 14 and 15 exerted potent cytotoxicity against CCRF-CEM cells, with IC50 values of 5.5 and 3.5 μM, respectively, whereas 26, 28, 33, and 34 significantly inhibited RSL3-induced ferroptosis, with EC50 values of 11.6, 7.2, 11.8, and 2.2 μM, respectively.
科研通智能强力驱动
Strongly Powered by AbleSci AI