Two New Alkaloids of the Endophytic Fungus Rhizopus oryzae From Atractylodes macrocephala Koidz

ABSTRACT Two new alkaloids, named migenomycin I ( 1 ) and II ( 2 ), along with nine known compounds ( 3–11 ), were isolated from the fungus Rhizopus oryzae from Atractylodes macrocephala Koidz. The structures of compounds 1 and 2 were determined by spectroscopic methods (MS, NMR, and CD). All compounds were isolated from Rhizopus oryzae for the first time. In addition, the antitumor activities of compounds 1 and 2 and the hypoglycemic activities of most compounds were evaluated.