微生物群
囊性纤维化
伊瓦卡夫托
囊性纤维化跨膜传导调节器
仿形(计算机编程)
肠道微生物群
肠道微生物群
医学
计算生物学
生物
生物信息学
遗传学
计算机科学
操作系统
作者
Seth A. Reasoner,Rachel Bernard,Adam Waalkes,Kelsi Penewit,Janessa D. Lewis,Andrew G. Sokolow,Rebekah F. Brown,Kathryn M. Edwards,Stephen J. Salipante,Maria Hadjifrangiskou,Maribeth R. Nicholson
出处
期刊:MBio
[American Society for Microbiology]
日期:2024-01-26
卷期号:15 (2)
被引量:3
标识
DOI:10.1128/mbio.01935-23
摘要
Cystic fibrosis (CF) is an autosomal recessive disease with significant gastrointestinal symptoms in addition to pulmonary complications. Recently approved treatments for CF, CF transmembrane conductance regulator (CFTR) modulators, are anticipated to substantially improve the care of people with CF and extend their lifespans. Prior work has shown that the intestinal microbiome correlates with health outcomes in CF, particularly in children. Here, we study the intestinal microbiome of children with CF before and after the CFTR modulator, ELX/TEZ/IVA. We identify promising improvements in microbiome diversity, reduced measures of intestinal inflammation, and reduced antibiotic resistance genes. We present specific bacterial taxa and protein groups which change following ELX/TEZ/IVA. These results will inform future mechanistic studies to understand the microbial improvements associated with CFTR modulator treatment. This study demonstrates how the microbiome can change in response to a targeted medication that corrects a genetic disease.
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