Converting heterotrophic Saccharomyces cerevisiae to a synthetic methylotroph

Abstract

It is challenging to convert a non-methylotrophic yeast to a synthetic methylotroph. In a recently described new method, Nielsen, Keasling, Chen, Bai, and coworkers show that Saccharomyces cerevisiae can be engineered to grow solely on methanol, which potentially emerges as a promising platform for one-carbon (C1)-based biomanufacturing.