鼻腔给药
药物输送
药品
生物制药
药理学
药物输送到大脑
鼻子
靶向给药
医学
中枢神经系统
纳米技术
血脑屏障
生物
外科
内科学
材料科学
生物技术
作者
Yaoxing Chen,Chenyun Zhang,Yukun Huang,Yuxiao Ma,Qingxiang Song,Hongzhuan Chen,Gan Jiang,Xiaoling Gao
标识
DOI:10.1016/j.addr.2024.115196
摘要
Intranasal delivery provides a direct and non-invasive method for drugs to reach the central nervous system. Nanoparticles play a crucial role as carriers in augmenting the efficacy of brain delivery. However, the interaction between nanoparticles and the nose-to-brain pathway and how the various biopharmaceutical factors affect brain delivery efficacy remains unclear. In this review, we comprehensively summarized the anatomical and physiological characteristics of the nose-to-brain pathway and the obstacles that hinder brain delivery. We then outlined the interaction between nanoparticles and this pathway and reviewed the biomedical applications of various nanoparticulate drug delivery systems for nose-to-brain drug delivery. This review aims at inspiring innovative approaches for enhancing the effectiveness of nose-to-brain drug delivery in the treatment of different brain disorders.
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