活性氧
炎症
清除
化学
广谱
氧气
医学
免疫学
生物化学
抗氧化剂
组合化学
有机化学
作者
Fujing Wang,Haitao Yuan,Jing Shen,Zhijie Li,J. Li,Piao Luo,Qian Zhang,Wei Huang,Xiaoxian Wang,Jingbo Ma,Wenqiao Zhang,Chunjin Fu,Jichao Sun,Xin Sun,Jigang Wang,Wei Xiao
出处
期刊:ACS materials letters
[American Chemical Society]
日期:2024-03-07
卷期号:6 (4): 1304-1316
标识
DOI:10.1021/acsmaterialslett.3c01627
摘要
Reactive oxygen species (ROS) related oxidative stress causes an inflammatory storm and massive hepatocyte necrosis in acute liver injury (ALI). Necrotic hepatocytes trigger an irreversible secondary injury mediated by the innate immune system, potentially leading to liver failure or even death. Therefore, antioxidant therapies may be hepatoprotective. Herein, we have reported novel metal–phenolic nanozymes (CA-Mn NPs) with broad-spectrum ROS scavenging ability. CA-Mn NPs inhibited hepatocyte apoptosis and prevented the recruitment of inflammatory monocytes through antioxidant mechanism in vitro. Meanwhile, CA-Mn NPs suppressed cell apoptosis and the levels of inflammatory factors in carbon tetrachloride (CCl4)-induced ALI mice. We further focused on the anti-inflammatory mechanisms of CA-Mn NPs and found that the Nrf2-Keap1 signaling pathway was upregulated and the NF-κB p65 pathway was downregulated. Besides, CA-Mn NPs restored the autophagic function and converted the M1 type macrophages to the M2 type. RNA sequencing also confirmed that CA-Mn NPs regulate the expression of apoptotic, autophagic, and inflammatory genes. Overall, the clearance of ROS by CA-Mn NPs prevented inflammation and apoptosis in ALI mice, providing new insights for the development of therapeutic strategies.
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