Pediatric Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease With Combined Central and Peripheral Demyelination

Recently, anti-myelin oligodendrocyte glycoprotein (MOG) antibody-positive combined central and peripheral demyelination has been reported 1 Rinaldi S. Davies A. Fehmi J. et al. Overlapping central and peripheral nervous system syndromes in MOG antibody-associated disorders. Neurol Neuroimmunol Neuroinflamm. 2020; 8: e924 Crossref PubMed Scopus (53) Google Scholar , 2 Nakamura T. Kaneko K. Watanabe G. et al. Myelin oligodendrocyte glycoprotein-IgG-positive, steroid-responsive combined central and peripheral demyelination with recurrent peripheral neuropathy. Neurol Sci. 2021; 42: 1135-1138 Crossref PubMed Scopus (14) Google Scholar , 3 Do Campo R.V. Stephans A. Collazo I.V.M. Rubin D.I. MOG antibodies in combined central and peripheral demyelination syndromes. Neurol Neuroimmunol Neuroinflamm. 2018; 5: e503 Crossref PubMed Scopus (45) Google Scholar , 4 Sundaram S. Nair S.S. Jaganmohan D. Unnikrishnan G. Nair M. Relapsing lumbosacral myeloradiculitis: an unusual presentation of MOG antibody disease. Mult Scler. 2020; 26: 509-511 Crossref PubMed Scopus (32) Google Scholar , 5 Nakamura M. Fujimori J. Kobayashi M. et al. Refractory case of myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis with lumbosacral radiculitis. Clin Exp Neuroimmunol. 2020; 11: 126-130 Crossref Scopus (5) Google Scholar ; however, pediatric cases are rare. 1 Rinaldi S. Davies A. Fehmi J. et al. Overlapping central and peripheral nervous system syndromes in MOG antibody-associated disorders. Neurol Neuroimmunol Neuroinflamm. 2020; 8: e924 Crossref PubMed Scopus (53) Google Scholar Here, we report a pediatric case of MOG-positive combined central and peripheral demyelination in a unique clinical course, with the onset of facial paralysis, external ophthalmoplegia, and peripheral neuropathy followed by encephalitis and optic neuritis.