吹覆盆子
失调
势垒函数
炎症
TLR4型
双歧杆菌
多糖
肠道菌群
益生元
脂多糖
乳酸菌
下调和上调
生物
微生物学
食品科学
化学
细胞生物学
免疫学
生物化学
内分泌学
基因
发酵
作者
Yuzhe Huang,Jingjing Hu,Qijun Xia,Maomao Tang,Yuxiao Wang,Guichun Wang,Xinyuan Shao,Hao Yuan,Shuhan Li,Peng Huang,Chengjun Peng,Jian Guo,Shuangying Gui
标识
DOI:10.1016/j.ijbiomac.2024.129825
摘要
Raspberry, a traditional medicine food homology species, has important benefits in patients with metabolic syndrome. However, the mechanism of raspberry polysaccharides (RP) on obesity remains unclear. In our study, we showed that RP intervention is negatively associated with body weight gain, hyperlipidemia, inflammation, and fat accumulation in obese mice. RP ameliorated HFD-induced gut microbiota dysbiosis, produced short-chain fatty acids, maintained intestinal barrier integrity, and prevented metabolic endotoxemia, manifested by decreased host lipopolysaccharide level, and increased colon expression of tight junction proteins. These effects might be related with driven by a SCFAs-producing bacterium and downregulation of TLR4/NF-κB signaling transduction. Notably, the abundance of Ruminococcaceae_UCG − 014, Lactobacillus taiwanensis, Bifidobacterium pseudolongum, and Turicibacter are markedly correlated with enhanced intestinal barrier function induced by RP treatment. Thus, we believe that RP could be as a potential health supplement or prebiotic for obesity therapy.
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