立体中心
邻接
化学
对映选择合成
炔烃
催化作用
位阻效应
产量(工程)
组合化学
立体化学
有机化学
冶金
材料科学
作者
Ting Wang,Yong You,Zhen-Hua Wang,Jian‐Qiang Zhao,Yanping Zhang,Jun-Qing Yin,Ming‐Qiang Zhou,Bao‐Dong Cui,Wei‐Cheng Yuan
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-02-17
卷期号:25 (8): 1274-1279
被引量:2
标识
DOI:10.1021/acs.orglett.3c00075
摘要
A copper-catalyzed diastereo- and enantioselective decarboxylative [3 + 2] cyclization reaction of alkyne-substituted cyclic carbamates with azlactones has been established. A range of optically pure γ-butyrolactams bearing two vicinal tetrasubstituted carbon stereocenters were obtained in high yields with good to excellent stereoselectivities (up to 99% yield, 99:1 dr, and 99% ee). This is the first example of asymmetric synthesis γ-butyrolactams containing sterically congested vicinal tetrasubstituted stereocenters via a decarboxylative cyclization pathway.
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