光动力疗法
光热治疗
荧光
纳米技术
化学
碳纤维
柠檬酸
癌症研究
材料科学
医学
光学
生物化学
物理
有机化学
复合材料
复合数
作者
Yahui Zhang,Haoyu Xia,Mengdie Yang,Hairong Li,Feishi Shan,Yilong Chen,Xue Yue,Zhouyu Wang,Xiao‐Qi Yu
标识
DOI:10.1016/j.cclet.2023.108197
摘要
Applying the fluorescent carbon dots as smart materials in anticancer therapy is of great interest. However, carbon dots for multimodal synergistic anticancer therapy, especially for the triple modality, is rarely reported. Herein, we successfully synthesized OCDs by citric acid and (1R,2S)-2-amino-1,2-diphenylethan-1-ol, which show aggregation-induced emission property and two-photon fluorescence imaging. Meanwhile, OCDs are ideal photosensitizers for photothermal therapy under 808 nm and Type I photodynamic therapy with white light. Hydroxyl radicals, generated by Type I photodynamic therapy based on OCDs can transform protumoral M2 macrophages into antitumoral M1 macrophages, which exhibited immunotherapy ability. The synergism trimodal of OCDs results in potent anticancer efficacy, showing great potential in cancer therapy.
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