衰老
生物标志物
转录组
细胞衰老
计算生物学
生物
神经科学
细胞生物学
基因表达
基因
遗传学
表型
作者
Lei Zhang,Lei Zhang,Elijah Torbenson,Paul D. Robbins,Lei Zhang,Lei Zhang
标识
DOI:10.1016/j.arr.2024.102403
摘要
Cellular senescence is a cell fate driven by different types of stress, where damaged cells exit from the cell cycle and, in many cases, develop an inflammatory senescence-associated secretory phenotype (SASP). Senescence has often been linked to driving aging and the onset of multiple diseases conferred by the harmful SASP, which disrupts tissue homeostasis and impairs the regular function of many tissues. This phenomenon was first observed in vitro when fibroblasts halted replication after approximately 50 population doublings. In addition to replication-induced senescence, factors such as DNA damage and oncogene activation can induce cellular senescence both in culture and in vivo. Despite their contribution to aging and disease, identifying senescent cells in vivo has been challenging due to their heterogeneity. Although senescent cells can express the cell cycle inhibitors p16
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